In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma
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چکیده
منابع مشابه
A novel GIT2-BRAF fusion in pilocytic astrocytoma
BACKGROUND KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions of BRAF with other partner genes, as well as other genetic alterations not involving BRAF but also leading to MAPK pathway activation have been described rarely. CASE PRESENTATION We present a new fusi...
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Cerebellar pilocytic Astrocytoma is a benign tumor, acounts for 80% of all cerebellar Astrocytoma, and has a relatively good prognosis. This tumor usually presents with Ataxia and in the case of hydrocephaly with raised intracranial pressure signs such as headeach, and vomiting. Treatment of this tumor is complete resection and if hydrocephally is present V.P. shunt should be inserted. In the c...
متن کاملNovel BRAF Alteration in a Sporadic Pilocytic Astrocytoma
Pilocytic astrocytoma (PA) is the most frequently encountered glial tumor (glioma or astrocytoma) in children. Recent studies have identified alterations in the BRAF serine/threonine kinase gene as the likely causative mutation in these childhood brain tumors. The majority of these genetic changes involve chromosome 7q34 tandem duplication, resulting in aberrant BRAF fusion transcripts. In this...
متن کاملA new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). These features may serve as diagnostic and prognostic markers, and also facilitate development of targeted ...
متن کاملCorrection: A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma
[This corrects the article DOI: 10.1371/journal.pone.0175638.].
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0242521